Future alignment of the the SNOMED and NUVA concept models

Hello @jcase and @fkaag. Now that the dust has somewhat settled on our migration over to these forum pages, I thought we might be able to pick up our discussion on the potential for further alignment of the SNOMED CT and NUVA concept models.

As I see it, we have two lines of enquiry here (any others?):

  1. That NUVA specifies the disease that each vaccine is intended to protect against.
  2. That NUVA uses valence rather than ‘has ingredient’, and that this is the gap that prevents NUVA concepts from subsuming under SNOMED parents.

NUVA specifies the Disease

A blunt first step we could take here would be to add an attribute into the NUVA extension which links the vaccine to the disease, but that doesn’t enrich the International Edition at all, or improve subsumption. I think the problem on our side is that the disease we’re targeting cannot be considered a defining property of the vaccine. I wonder if it could be a candidate for expression as an “additional” relationship, that would not participate in classification.

We seem to be missing a link in SNOMED CT in that I can see the pathogen for a disorder, but there’s no link to the antigen (in terms of the model) that would let me arrive at the vaccine.

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Valence vs Has Ingredient

Is it fair to say, Jim, that there is no short or medium term future in which the International Edition adopts the concept of Valence?

I wondered if - given that we know the target disease - there would be a way to augment the valence with a calculated active ingredient, and then define a role chain so that the active ingredient on the valence behaved as if it were directly on the vaccine. Might need to ask @ygao’s advice there.

Another approach that I’m thinking of here is : what if - in the NUVA extension only - we were to add a secondary axiom to International concepts which introduced the Valence, leading to the NUVA concept subsuming correctly. We could use the NUVA map to SNOMED vaccines in order to identify where these additional axioms should be added.

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@pwilliams

As we have talked about in the past, contrary to the vaccine targeting a specific disease, the vaccine actually targets the organism that causes the disease. This would be more precise as there are often multiple agents that can cause the same clinical signs (e.g. Influenza-like illneses), RSV, etc. I think adding a relationship to the vaccine model linking the vaccine to the target agent would be a good first step.

I do not at present see a path where the International release would adopt the notion of valence.

You are correct though that there is no direct linkage currently between an antigen of an organism and the organism itself. The role chain approach would need to be evaluated over an explicit named relationship between the organism part and the organism. That issue wil be discussed in Antwerp related to the use cases for making that relationship explicit. However, in the context of the vaccine model, it may not be necessary if there is both HAS ACTIVE INGREDIENT and HAS TARGET AGENT in the model.

Your suggestion about adding valence as a secondary axiom is good as it allows for both representations of vaccines while allowing for proper subsumption in the international release.

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